Hanford Thyroid Disease Study Final Report

By Davis, Scott

Excerpt
I. INTRODUCTION: The Hanford Thyroid Disease Study (HTDS) was conducted by a team of investigators at the Fred Hutchinson Cancer Research Center (FHCRC) under contract to the Centers for Disease Control and Prevention (CDC) Radiation Studies Branch. The Study Management Team (SMT) which had primary responsibility for the design and conduct of the investigation, consisted of Scott Davis, Ph.D. (epidemiology), Kenneth Kopecky, Ph.D. (biostatistics), and Thomas Hamilton, M.D., Ph.D. (endocrinology). Bruce Amundson, M.D. (family medicine) was a member of the SMT through August 1998. Ms. Peggy Adams Myers served as Project Manager through the release of the Draft Final Report. Ms. Beth King assumed responsibility for project management thereafter. In addition to the FHCRC team, the study employed Dr. Robert Griep as an expert consultant on thyroid disease. Dr. Bruce Kulander served as the pathologist who reviewed all pathological specimens. Four radiologists at Seattle Nuclear Medicine/Ultrasound Associates interpreted the thyroid ultrasound scans. Administrative, statistical, and technical staff reported directly to the Project Manager and the SMT. The clinical component of the HTDS was directed by Dr. Hamilton, with the assistance of the HTDS study physicians in conducting thyroid examinations. Study operations were based at the FHCRC in Seattle, with a field office in the Tri-Cities for the Subject Tracing component.

Table of Contents
TABLE OF CONTENTS EXECUTIVE SUMMARY I. INTRODUCTION ………………..……………………………………………………...1 II. BACKGROUND …………………..….………………………………………………….4 A. Historical Perspective ……….…..………………………………………………….4 B. Ionizing Radiation and Thyroid Disease ……….…………………………………...9 B.1. Thyroid Neoplasia: Exposure to External Photon Radiation …….………...9 B.2. Thyroid Neoplasia: Exposure to Radioactive Iodine …………….………..10 B.2.a. Medical Exposures to Radioiodine ……………………….……….10 B.2.b. Environmental Exposures to Radioiodine ……………….………..11 B.2.b.1. Utah ……………………………………………………….11 B.2.b.2. Marshall Islands …..…………………………………..……11 B.2.b.3 Chernobyl ……………………………………………..……12 B.2.c. Relative Biological Effectiveness of I-131 in the Induction of Thyroid Cancer …………………………………………………….13 B.3. Hypothyroidism …………………………………………………………...14 B.4. Autoimmune Thyroiditis …………………………………………………..14 C. Ionizing Radiation and Parathyroid Disease ……………………………………...16 C.1. Hyperparathyroidism: Exposure to External Photon Radiation ……..…...16 C.2. Hyperparathyroidism: Exposure to Radioactive Iodine ……………..……17 D. Ultrasound-Detected Abnormalities of the Thyroid (Thyroid UDAs) ………..…...18 D.1. Prevalence of Thyroid UDAs …………………………………………….18 D.2. Specificity of Thyroid Ultrasonography in Predicting Thyroid Cancer …...19 D.3. Ionizing Radiation and Thyroid UDAs …………………………………….20 III. STUDY OBJECTIVES …………………………….………………………………..…21 IV. STUDY DESIGN …………………………………………………………………….....22 A. Eligibility Criteria ………………………………………………………………....22 A.1. Mother's Residence at the Time of the Particpant's Birth ……………..…..22 A.2. Year of Birth …………………………………………………………..…...30 A.3. Other Possible Criteria ………………………………………………..…..33 B. Definition of Evaluable Participant ……………………………………………..…34 C. Outcome Criteria ………………………………………………………………..…35 C.1. Thyroid Cancer …………………………………………………………....35 C.2. Benign Thyroid Nodule ………………………………………………….....35 C.3. Any Thyroid Nodule …………………………………………………….…36 C.4. Hypothyroidism …………………………………………………………...36 C.5. Autoimmune (Hashimoto’s) Thyroiditis ……………………………….….36 C.6. Graves Disease …………………………………………………….……...37 C.7. Autoimmune Thyroid Disease ……………………………………..………37 C.8. Hyperthyroidism ………………………………………………….……….37

Book Id: WPLBN0000087104
Format Type: PDF eBook
File Size: 14.17 MB
Reproduction Date: 2005
Full Text

Title:

Hanford Thyroid Disease Study Final Report

Author:

Davis, Scott

Volume:

Language:

English

Subject:

Health., Medical research, Medical reports

Collection:

Medical Library Collection

Subcollection:

Historic
Publication Date:

Publisher:

Centers for Disease Control and Prevention

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