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Plos One : Force Spectroscopy Measurements Show That Cortical Neur...

By: Etienne Dague

Description : In ischemic and traumatic brain injury, hyperactivated glutamate (N-methyl-D-aspartic acid, NMDA) and sodium (Nav) channels trigger excitotoxic neuron death. Na+, Ca++ and H2O influx into affected neurons elicits swelling (increased cell volume) and pathological blebbing (disassociation of the plasma membrane’s bilayer from its spectrin-actomyosin matrix). Though usually conflated in injured tissue, cell swelling and blebbing are distinct processes. Around ...

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Plos One : the Deinococcus Radiodurans Dr1245 Protein, a Ddrb Part...

By: Oleg Y. Dmitriev

Description : The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in gro...

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Plos One : Milligram Production and Biological Activity Characteri...

By: Nathalie Signoret

Description : Human chemokine receptor CCR3 (hCCR3) belongs to the G protein-coupled receptors (GPCRs) superfamily of membrane proteins and plays major roles in allergic diseases and angiogenesis. In order to study the structural and functional mechanism of hCCR3, it is essential to produce pure protein with biological functions on a milligram scale. Here we report the expression of hCCR3 gene in a tetracycline-inducible stable mammalian cell line. A cell clone with high...

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Plos One : McM10 Self-association is Mediated by an N-terminal Coi...

By: Sergey Korolev

Description : Minichromosome maintenance protein 10 (Mcm10) is an essential eukaryotic DNA-binding replication factor thought to serve as a scaffold to coordinate enzymatic activities within the replisome. Mcm10 appears to function as an oligomer rather than in its monomeric form (or rather than as a monomer). However, various orthologs have been found to contain 1, 2, 3, 4, or 6 subunits and thus, this issue has remained controversial. Here, we show that self-associatio...

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Plos One : Effect of Blue Light on Endogenous Isopentenyladenine a...

By: Miguel A. Blazquez

Description : Light is one of the most important factor influencing plant growth and development all through their life cycle. One of the well-known light-regulated processes is de-etiolation, i.e. the switch from skotomorphogenesis to photomorphogenesis. The hormones cytokinins (CKs) play an important role during the establishment of photomorphogenesis as exogenous CKs induced photomorphogenesis of dark-grown seedlings. Most of the studies are conducted on the plant mod...

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Plos One : a Key Role for Nectin-1 in the Ventral Hippocampus in C...

By: Georges Chapouthier

Description : Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-interactions are important for the proper formation of synapses. In the hippocampus, nectin-1 and nectin-3 localize at puncta adherentia junctions and may play a role in synaptic plasticity, a mechanism essen...

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Plos One : Comparative Transcriptome Profiling of Dairy Goat Micro...

By: Liang-hu Qu

Description : This study reveals the first miRNAs profile related to the biology of the mammary gland in the dairy goat. The characterization of these miRNAs could contribute to a better understanding of the molecular mechanisms of lactation physiology and mammary gland development in the dairy goat.

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Plos One : Pneumocystis Jirovecii Pneumonia in Tropical and Low an...

By: Sten H. Vermund

Description : There is a positive relationship between GDP and risk of PCP diagnosis. Although failure to diagnose infection in poorer countries may contribute to this, we also hypothesise that poverty exposes at-risk patients to a wide range of infections and that the relatively non-pathogenic P. jirovecii is therefore under-represented. As LMIC develop economically they eliminate the conditions underlying transmission of virulent infection : P. jirovecii, ubiquitous in...

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Plos One : Identification of Potential Plk1 Targets in a Cell-cycl...

By: Kyung S. Lee

Description : Polo like kinase 1 (Plk1) is a key player in orchestrating the wide variety of cell-cycle events ranging from centrosome maturation, mitotic entry, checkpoint recovery, transcriptional control, spindle assembly, mitotic progression, cytokinesis and DNA damage checkpoints recovery. Due to its versatile nature, Plk1 is considered an imperative regulator to tightly control the diverse aspects of the cell cycle network. Interactions among Plk1 polo box domain (...

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Plos One : Proprotein Convertase Subtilisin, Volume 8

By: Makoto Kanzaki

Description : Elevated LDL-cholesterol (LDLc) levels are a major risk factor for cardiovascular disease and atherosclerosis. LDLc is cleared from circulation by the LDL receptor (LDLR). Proprotein convertase subtilisin/kexin 9 (PCSK9) enhances the degradation of the LDLR in endosomes/lysosomes, resulting in increased circulating LDLc. PCSK9 can also mediate the degradation of LDLR lacking its cytosolic tail, suggesting the presence of as yet undefined lysosomal-targeting...

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Plos One : Increasing Visual Search Accuracy by Being Watched, Vol...

By: Francesco Di Russo

Description : In daily life, huge costs can arise from just one incorrect performance on a visual search task (e.g., a fatal accident due to a driver overlooking a pedestrian). One potential way to prevent such drastic accidents would be for people to modify their decision criterion (e.g., placing a greater priority on accuracy rather than speed) during a visual search. The aim of the present study was to manipulate the criterion by creating an awareness of being watched...

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Plos One : Shp-1 Phosphatase is a Critical Regulator in Preventing...

By: Jacques Zimmer

Description : Balance of signals generated from the engaged activating and inhibitory surface receptors regulates mature NK cell activities. The inhibitory receptors signal through immunoreceptor tyrosine based inhibitory motifs (ITIM), and recruit phosphatases such as SHP-1 to inhibit NK cell activation. To directly examine the importance of SHP-1 in regulating activities and cell fate of mature NK cells, we used our established lentiviral-based engineering protocol to ...

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Plos One : Acute Stress Induces Hyperacusis in Women with High Lev...

By: Berthold Langguth

Description : Women with high levels of emotional exhaustion become more sensitive to sound after an acute stress task. This novel finding highlights the importance of including emotional exhaustion in the diagnosis and treatment of hearing problems.

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Plos One : Data Acquisition for Conservation Assessments ; is the ...

By: De Garcia Leaniz

Description : When identifying conservation priorities, the accuracy of conservation assessments is constrained by the quality of data available. Despite previous efforts exploring how to deal with imperfect datasets, little is known about how data uncertainty translates into errors in conservation planning outcomes. Here, we evaluate the magnitude of commission and omission error, effectiveness and efficiency of conservation planning outcomes derived from three datasets...

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Plos One : Climate-driven Range Extension of Amphistegina Protista...

By: Purificación López-garcía

Description : Species-range expansions are a predicted and realized consequence of global climate change. Climate warming and the poleward widening of the tropical belt have induced range shifts in a variety of marine and terrestrial species. Range expansions may have broad implications on native biota and ecosystem functioning as shifting species may perturb recipient communities. Larger symbiont-bearing foraminifera constitute ubiquitous and prominent components of sha...

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Plos One : Atypical E2Fs Control Lymphangiogenesis Through Transcr...

By: Tsutomu Kume

Description : Lymphatic vessels are derived from venous endothelial cells and their formation is governed by the Vascular endothelial growth factor C (VegfC)/Vegf receptor 3 (Vegfr3: Flt4) signaling pathway. Recent studies show that Collagen and Calcium Binding EGF domains 1 protein (Ccbe1) enhances VegfC-dependent lymphangiogenesis. Both Ccbe1 and Flt4 have been shown to be indispensable for lymphangiogenesis. However, how these essential players are transcriptionally r...

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Plos One : Comparison of Platelet Ultrastructure and Elastic Prope...

By: Thiruma V. Arumugam

Description : Thrombo-embolic ischemic stroke is a serious and debilitating disease, and it remains the second most common cause of death worldwide. Tobacco smoke exposure continues to be responsible for preventable deaths around the world, and is a major risk factor for stroke. Platelets play a fundamental role in clotting, and their pathophysiological functioning is present in smokers and stroke patients, resulting in a pro-thrombotic state. In the current manuscript, ...

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Plos One : Inhibition of Pirfenidone on Tgf-beta2 Induced Prolifer...

By: Ed Manser

Description : Pirfenidone inhibits TGF-b2-induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04 at nontoxic concentrations. This effect may be achieved by down regulation of TGF-b/ SAMD signaling in SRA01/04 cells.

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Plos One : Hypothalamic Inhibition of Acetyl-coa Carboxylase Stimu...

By: Reury F.P. Bacurau

Description : Hypothalamic ACC inhibition can activate hepatic counter-regulatory response independent of hypothalamic AMPK activation

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Plos One : Protection by an Oral Disubstituted Hydroxylamine Deriv...

By: Steven Barnes

Description : Thy-1 is a cell surface protein that is expressed during the differentiation of retinal ganglion cells (RGCs). Optic nerve injury induces progressive loss in the number of RGCs expressing Thy-1. The rate of this loss is fastest during the first week after optic nerve injury and slower in subsequent weeks. This study was undertaken to determine whether oral treatment with a water-soluble N-hydroxy-2,2,6,6-tetramethylpiperidine derivative (OT-440) protects ag...

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